Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17724136 | 0.84 | PDE1B (0.56) | KDM4ETDP1PDE1BGRM2HTT | |
| SCHEMBL17724134 | 0.81 | PDE1B (0.46) | KDM4ETDP1PDE1BGRM2HTT | |
| SCHEMBL20605214 | 0.80 | KDM4E (0.45) | KDM4ETDP1PDE1BGRM2HTT | |
| SCHEMBL19532828 | 0.80 | SIGMAR1 (0.46) | KDM4ETDP1PDE1BGRM2HTT | |
| SCHEMBL19532826 | 0.77 | SIGMAR1 (0.46) | KDM4ETDP1PDE1BGRM2HTT | |
| SCHEMBL22711368 | 0.74 | KDM4E (0.53) | KDM4ETDP1PDE1BHTTLMNA | |
| SCHEMBL19309942 | 0.73 | ALDH1A1 (0.40) | KDM4EHTTGAAALDH1A1 | |
| SCHEMBL12383 | 0.73 | ALDH1A1 (0.55) | KDM4ETDP1HTTLMNAGAA | |
| SCHEMBL578799 | 0.71 | KDM4E (0.53) | KDM4ETDP1HTTLMNAGAA | |
| SCHEMBL5101706 | 0.71 | KDM4E (0.53) | KDM4ETDP1HTTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |