Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.43 |
| ▸ | PGR | P06401 | 10/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462616 | 0.86 | PGR (0.49) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL5034310 | 0.83 | NR3C1 (0.41) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL4423368 | 0.83 | MAPT (0.39) | NR3C1PGRARNR3C2 | |
| SCHEMBL2395535 | 0.82 | PGR (0.43) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL450303 | 0.81 | NR3C1 (0.43) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL1779600 | 0.79 | MAPT (0.40) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL2391814 | 0.78 | NR3C1 (0.49) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL5132462 | 0.77 | PGR (0.47) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL5040811 | 0.77 | NR3C1 (0.46) | NR3C1PGRARESR1ESR2 | |
| SCHEMBL1315415 | 0.77 | NR3C1 (0.42) | NR3C1PGRARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420635-B2 | Method for preventing or treating a glucocorticoid receptor-related disease | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2013-04-16 | — | — | US | claimed |
| US-8017775-B2 | 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-13 | — | — | US | claimed |