Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23940213 | 0.85 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23940225 | 0.82 | HDAC6 (0.56) | ALDH1A1HDAC1HDAC6SMN1; SMN2HPGD | |
| SCHEMBL3924368 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTMAPK1LMNA | |
| SCHEMBL15458754 | 0.76 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL23940238 | 0.76 | HTR3A (0.47) | SMN1; SMN2 | |
| SCHEMBL7121916 | 0.74 | SMN1; SMN2 (0.77) | ALDH1A1SMN1; SMN2GAAHPGDMEN1 | |
| SCHEMBL23940218 | 0.74 | ATM (0.58) | ALDH1A1SMN1; SMN2HPGDKDM4ECYP1A2 | |
| SCHEMBL13209353 | 0.73 | NR4A2 (0.65) | ALDH1A1SMN1; SMN2GAAKDM4EMAPT | |
| SCHEMBL12372688 | 0.73 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2GAAHPGDKMT2A | |
| SCHEMBL1397315 | 0.71 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2GAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | TYK2, JAK3, JAK1 | ALDH1A1 2637/4885HDAC1 714/4885HDAC6 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.