Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 7/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 7/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | SOD3 | P08294 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23426277 | 1.00 | SIGMAR1 (0.56) | SIGMAR1HRH2HRH1CA12CA1 | |
| SCHEMBL19032657 | 1.00 | SIGMAR1 (0.56) | SIGMAR1HRH2HRH1CA12CA1 | |
| SCHEMBL19032646 | 0.88 | CA12 (0.42) | SIGMAR1CA12CA1CA2CA4 | |
| SCHEMBL29329335 | 0.88 | CA12 (0.42) | SIGMAR1CA12CA1CA2CA4 | |
| SCHEMBL20562047 | 0.83 | CA12 (0.39) | SIGMAR1HRH2HRH1CA12CA1 | |
| SCHEMBL29001307 | 0.82 | SIGMAR1 (0.59) | SIGMAR1HRH2HRH1GNAO1GNAI3 | |
| SCHEMBL19040701 | 0.82 | SIGMAR1 (0.46) | SIGMAR1CA12CA1CA2CA4 | |
| SCHEMBL19032598 | 0.80 | GNAO1 (0.46) | SIGMAR1HRH2HRH1GNAO1GNAI3 | |
| SCHEMBL19040849 | 0.80 | GNAO1 (0.46) | SIGMAR1HRH2HRH1GNAO1GNAI3 | |
| SCHEMBL4061196 | 0.80 | CA12 (0.52) | CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896164-A1 | POLYNUCLEOTIDES ENCODING ALPHA-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE | ModernaTX, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |