Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 15/20 | 0.62 |
| ▸ | BMPR1A | P36894 | 15/20 | 0.62 |
| ▸ | ACVRL1 | P37023 | 15/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 15/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 14/20 | 0.62 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806976 | 0.89 | BMPR1B (0.77) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL24318078 | 0.89 | BMPR1B (0.77) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806938 | 0.88 | BMPR1B (0.62) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806887 | 0.88 | BMPR1B (0.72) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL5712357 | 0.81 | PIK3C3 (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL6838760 | 0.79 | MERTK (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL29373251 | 0.78 | BMPR1B (0.71) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL20995196 | 0.78 | BMPR1B (0.71) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL4682526 | 0.76 | PRKCI (0.67) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL13187806 | 0.76 | PRKCI (0.67) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3971177-B1 | AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | NOVARTIS AG (CH) | 2024-06-26 | — | — | EP | disclosed |
| EP-3487851-B1 | AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | NOVARTIS AG (CH) | 2021-10-20 | — | — | EP | disclosed |