Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 18/20 | 0.77 |
| ▸ | BMPR1A | P36894 | 18/20 | 0.77 |
| ▸ | ACVRL1 | P37023 | 18/20 | 0.77 |
| ▸ | ACVR1 | Q04771 | 18/20 | 0.77 |
| ▸ | TGFBR1 | P36897 | 17/20 | 0.77 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
| ▸ | ATR | Q13535 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806976 | 1.00 | BMPR1B (0.77) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806938 | 0.89 | BMPR1B (0.62) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL23940756 | 0.89 | BMPR1B (0.62) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806887 | 0.89 | BMPR1B (0.72) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL5712357 | 0.82 | PIK3C3 (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL20995206 | 0.81 | BMPR1B (0.74) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL20995207 | 0.81 | BMPR1B (0.74) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL20995061 | 0.81 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806989 | 0.81 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL6838760 | 0.80 | MERTK (0.60) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3971177-B1 | AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | NOVARTIS AG (CH) | 2024-06-26 | — | — | EP | disclosed |
| EP-3971177-A1 | AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS | Novartis AG (CH) | 2022-03-23 | — | — | EP | disclosed |