Veonetinib

Veonetinib

SCHEMBL239435

COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ccnc2cc1OCCN1CC(O)C2(CC2)C1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 7/20 0.63
PDGFRB P09619 3/20 0.63
RET P07949 2/20 0.54
MET P08581 6/20 0.53
AXL P30530 4/20 0.53
KIT P10721 2/20 0.53
FLT3 P36888 2/20 0.53
PLK4 O00444 1/20 0.53
GAK O14976 1/20 0.53
EPHB6 O15197 1/20 0.53
RIPK2 O43353 1/20 0.53
ERN1 O75460 1/20 0.53
STK10 O94804 1/20 0.53
MAP4K4 O95819 1/20 0.53
CHEK2 O96017 1/20 0.53
ABL1 P00519 1/20 0.53
EGFR P00533 1/20 0.53
ERBB2 P04626 1/20 0.53
LCK P06239 1/20 0.53
FYN P06241 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Veonetinib SCHEMBL26938478 1.00 KDR (0.63) KDRPDGFRBRETMETAXL
Veonetinib SCHEMBL31515075 1.00 KDR (0.63) KDRPDGFRBRETMETAXL
Veonetinib SCHEMBL30631724 1.00 KDR (0.63) KDRPDGFRBRETMETAXL
Veonetinib SCHEMBL26938477 1.00 KDR (0.63) KDRPDGFRBRETMETAXL
Veonetinib SCHEMBL31515076 1.00 KDR (0.63) KDRPDGFRBRETMETAXL
SCHEMBL242042 0.96 KDR (0.62) KDRPDGFRBRETMETAXL
SCHEMBL244278 0.92 KDR (0.64) KDRPDGFRBRETMETAXL
SCHEMBL242187 0.88 KDR (0.63) KDRPDGFRBRETMETAXL
SCHEMBL245590 0.84 KDR (0.64) KDRPDGFRBRETMETAXL
SCHEMBL240816 0.84 KDR (0.66) KDRPDGFRBRETMETAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230399313-A1 BIOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN-7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 US claimed
WO-2023239945-A1 BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 WO claimed
EP-2312950-B1 COMPOUNDS AS KINASE INHIBITORS ADVENCHEN LAB LLC (US) 2016-11-30 EP claimed
US-8211911-B2 Compounds as kinase inhibitors CHEN GUOQING PAUL (US) 2012-07-03 US claimed
JP-2012500269-A 2012-01-05 JP claimed
EP-2312950-A1 COMPOUNDS AS KINASE INHIBITORS Advenchen Laboratories, LLC (US) 2011-04-27 EP claimed
US-20100048599-A1 Compounds As Kinase Inhibitors CHEN GUOQING PAUL 2010-02-25 US claimed
WO-2010021918-A1 COMPOUNDS AS KINASE INHIBITORS ADVENCHEN LABORATORIES, LLC (US) 2010-02-25 WO claimed
US-20230399313-A1 BIOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN-7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 US disclosed
US-20230399313-A1 BIOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN-7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 US disclosed
WO-2023239945-A1 BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 WO disclosed
WO-2023239945-A1 BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 WO disclosed
WO-2023239945-A1 BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 WO disclosed
WO-2023239945-A1 BTOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5- YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN- 7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS Advenchen Pharmaceuticals, LLC (US) 2023-12-14 WO disclosed
EP-2312950-A1 COMPOUNDS AS KINASE INHIBITORS Advenchen Laboratories, LLC (US) 2011-04-27 EP disclosed
US-20100048599-A1 Compounds As Kinase Inhibitors CHEN GUOQING PAUL 2010-02-25 US disclosed
US-20100048599-A1 Compounds As Kinase Inhibitors CHEN GUOQING PAUL 2010-02-25 US disclosed
US-20100048599-A1 Compounds As Kinase Inhibitors CHEN GUOQING PAUL 2010-02-25 US disclosed
WO-2010021918-A1 COMPOUNDS AS KINASE INHIBITORS ADVENCHEN LABORATORIES, LLC (US) 2010-02-25 WO disclosed
WO-2010021918-A1 COMPOUNDS AS KINASE INHIBITORS ADVENCHEN LABORATORIES, LLC (US) 2010-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399313-A1 BIOLOGICAL ACTIVITIES OF 5-(2-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)ETHYL)-5-AZASPIRO[2.4]-HEPTAN-7-OL CRYSTALLINE, PHOSPHORIC ACID SALT AND ITS ENANTIOMERS LPXN, ALPP, RCC1 KDR 2108/4885PDGFRB 2086/4885RET 4361/4885
US-20100048599-A1 Compounds As Kinase Inhibitors MAP3K1, MAP3K5, MAP3K6 KDR 44/4885PDGFRB 148/4885RET 155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.