Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048548 | 0.86 | HRH3 (0.64) | HRH3LTA4HKCNH2 | |
| SCHEMBL18713086 | 0.83 | LTA4H (0.54) | HRH3SIGMAR1LTA4HKCNH2 | |
| SCHEMBL23179559 | 0.82 | HRH3 (0.49) | HRH3SIGMAR1IKZF2KCNH2 | |
| SCHEMBL15483888 | 0.81 | KDM4E (0.50) | HRH3PDE1BKCNH2 | |
| SCHEMBL20160684 | 0.80 | CXCR4 (0.49) | HRH3ADRB1SIGMAR1CHRM2CXCR4 | |
| SCHEMBL23179756 | 0.79 | HRH3 (0.47) | HRH3LTA4HIKZF2KCNH2 | |
| SCHEMBL22812069 | 0.79 | HRH3 (0.47) | HRH3SIGMAR1SLC6A4LTA4HIKZF2 | |
| SCHEMBL18705095 | 0.79 | HRH3 (0.52) | HRH3SIGMAR1LTA4HKCNH2 | |
| SCHEMBL23126249 | 0.78 | HRH3 (0.46) | HRH3SIGMAR1LTA4HIKZF2KCNH2 | |
| SCHEMBL20328040 | 0.77 | HRH3 (0.45) | HRH3SIGMAR1LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021208963-A1 | BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-10-21 | — | — | WO | disclosed |