Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26707238 | 1.00 | FAAH (0.41) | FAAHPOLBKMT2AMEN1EPHX1 | |
| SCHEMBL25725820 | 0.98 | POLB (0.41) | FAAHPOLBKMT2AMEN1EPHX1 | |
| SCHEMBL23695881 | 0.95 | POLB (0.41) | FAAHPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL25880927 | 0.93 | EPHX2 (0.42) | FAAHPOLBKMT2AMEN1EPHX1 | |
| SCHEMBL26406285 | 0.87 | KMT2A (0.37) | FAAHPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL23945950 | 0.84 | KMT2A (0.44) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23945482 | 0.84 | KMT2A (0.44) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12989912 | 0.83 | ALDH1A1 (0.50) | POLBKMT2AMEN1EPHX1ALDH1A1 | |
| SCHEMBL21965957 | 0.82 | FAAH (0.39) | FAAHPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL21107467 | 0.81 | KDM4E (0.57) | FAAHKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-27 | — | — | US | disclosed |
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | FAAH 1771/4885POLB 2088/4885KMT2A 445/4885 |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | FAAH 1771/4885POLB 2088/4885KMT2A 445/4885 |
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | FAAH 1771/4885POLB 2088/4885KMT2A 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.