Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16900141 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A | |
| SCHEMBL26037406 | 0.84 | HTR2C (0.47) | SMN1; SMN2ALDH1A1CYP2C19HRH1BCHE | |
| SCHEMBL21997640 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP2C19NPC1RAB9AMEN1 | |
| SCHEMBL25726362 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP2C19NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL29152472 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP2C19NPC1RAB9AMEN1 | |
| SCHEMBL27278124 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1CYP2C19BCHENPC1 | |
| SCHEMBL22280532 | 0.81 | LTA4H (0.48) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A | |
| SCHEMBL23027037 | 0.81 | LTA4H (0.48) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A | |
| SCHEMBL16228724 | 0.79 | NPC1 (0.53) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A | |
| SCHEMBL24251635 | 0.79 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | SMN1; SMN2 2647/4885ALDH1A1 2776/4885CYP2C19 3990/4885 |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | SMN1; SMN2 2647/4885ALDH1A1 2776/4885CYP2C19 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.