SCHEMBL2394719

SCHEMBL2394719

Fc1ccc(Oc2cccc(Br)c2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.59
MAPT P10636 2/20 0.45
MEN1 O00255 1/20 0.45
MITF O75030 1/20 0.45
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
GFER P55789 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NLRP1 Q9C000 1/20 0.45
NOD2 Q9HC29 1/20 0.45
PGR P06401 1/20 0.43
EGFR P00533 1/20 0.41
SOS1 Q07889 1/20 0.40
HSPB1 P04792 1/20 0.40
FNTA P49354 1/20 0.40
FNTB P49356 1/20 0.40
CHEK1 O14757 1/20 0.40
KDR P35968 1/20 0.40
CDK8 P49336 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3838974 0.89 ALDH1A1 (0.54) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL3839157 0.89 ALDH1A1 (0.54) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL27443501 0.88 MAPT (0.50) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL3838956 0.87 SMN1; SMN2 (0.58) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL3899847 0.86 MAOB (0.59) MAOBMAPTALDH1A1EGFR
SCHEMBL30633275 0.85 MAOB (0.55) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL3840708 0.85 MAOB (0.55) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL6289255 0.85 SMN1; SMN2 (0.60) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL6290665 0.85 SMN1; SMN2 (0.60) MAOBMAPTMEN1MITFALDH1A1
SCHEMBL4569951 0.85 SMN1; SMN2 (0.60) MAOBMAPTMEN1MITFALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115084655-A Electrolyte, preparation method thereof and lithium metal battery containing electrolyte 蜂巢能源科技(无锡)有限公司 2022-09-20 CN claimed
EP-0351214-A1 Anti-inflammatory aryl derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1990-01-17 EP claimed
CN-115863765-A Electrolyte and battery comprising same 蜂巢能源科技股份有限公司 2023-03-28 CN disclosed
CN-115084655-A Electrolyte, preparation method thereof and lithium metal battery containing electrolyte 蜂巢能源科技(无锡)有限公司 2022-09-20 CN disclosed
EP-3912977-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES BioMarin Pharmaceutical Inc. (US) 2021-11-24 EP disclosed
EP-3046920-B1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES BIOMARIN PHARM INC (US) 2021-08-04 EP disclosed
US-9796708-B2 Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors ABBVIE INC. (US) 2017-10-24 US disclosed
US-20160229830-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES BIOMARIN PHARMACEUTICAL INC. 2016-08-11 US disclosed
US-20160229830-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES BIOMARIN PHARMACEUTICAL INC. 2016-08-11 US disclosed
US-20160060257-A1 PYRROLO [2,3-B] PYRIDINE CDK9 KINASE INHIBITORS ABBVIE INC. (US) 2016-03-03 US disclosed
EP-2970278-A1 PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS AbbVie Inc. (US) 2016-01-20 EP disclosed
EP-0720598-A1 PHENOXYPHENYL CYCLOPENTENYL HYDROXYUREAS PFIZER INC. (US) 1996-07-10 EP disclosed
EP-0657459-A1 Thienothiazine derivates, process for their preparation and their use as anti-inflammatory and analgesic agents Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. (AT) 1995-06-14 EP disclosed
EP-0558563-B1 ANTI-INFLAMMATORY COMPOUNDS WELLCOME FOUND (GB) 1995-03-29 EP disclosed
WO-1995005360-A1 PHENOXYPHENYL CYCLOPENTENYL HYDROXYUREAS PFIZER INC. (US) 1995-02-23 WO disclosed
EP-0384594-B1 Anti-inflammatory aryl derivatives WELLCOME FOUND (GB) 1993-10-27 EP disclosed
EP-0558563-A1 ANTI-INFLAMMATORY COMPOUNDS. WELLCOME FOUND (GB) 1993-09-08 EP disclosed
WO-1992009567-A1 ANTI-INFLAMMATORY COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-06-11 WO disclosed
EP-0384594-A1 Anti-inflammatory aryl derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1990-08-29 EP disclosed
EP-0351214-A1 Anti-inflammatory aryl derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1990-01-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160060257-A1 PYRROLO [2,3-B] PYRIDINE CDK9 KINASE INHIBITORS CDK9, CDK19, CDK3 MAOB 918/4885MAPT 2806/4885MEN1 2578/4885
US-20160229830-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES GBA1, UGCG, GBA2 MAOB 989/4885MAPT 2871/4885MEN1 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.