Citric Acid

Citric Acid

SCHEMBL2394724

CC(O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[Zr]

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.37
ALDH1A1 P00352 2/20 0.65
TP53 P04637 1/20 0.48
CPT2 P23786 1/20 0.47
ACLY P53396 1/20 0.47
TSHR P16473 2/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
ALOX15 P16050 1/20 0.42
HMGCR P04035 1/20 0.41
CHRM1 P11229 1/20 0.41
TBXA2R P21731 1/20 0.41
ADRA1A P35348 1/20 0.41
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
SLC13A5 Q86YT5 4/20 0.38
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL653301 0.98 ALDH1A1 (0.68) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL27588805 0.98 ALDH1A1 (0.68) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL9387453 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL5048408 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL2879372 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL25376180 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL3880785 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL7125976 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL20521417 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL17686702 0.96 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4624795-A Aqueous acid gels and use thereof BJ-TITAN SERVICES COMPANY (US) 1986-11-25 US claimed
US-20250368890-A1 ANTI-CAKING OR BLOCKING AGENT FOR TREATING SOLID ACID PRECURSOR ADDITIVES USED IN TREATING SUBTERRANEAN FORMATIONS LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2025-12-04 US disclosed
US-11326088-B2 Low temperature diversion in well completion operations using natural mineral compound LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2022-05-10 US disclosed
US-20210403800-A1 ANTI-CAKING OR BLOCKING AGENT FOR TREATING SOLID ACID PRECURSOR ADDITIVES USED IN TREATING SUBTERRANEAN FORMATIONS LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2021-12-30 US disclosed
WO-2021262855-A1 SOLID ACID PRECURSOR ADDITIVE COMPRISING AN ANTI-CAKING AGENT, USED IN TREATING SUBTERRANEAN FORMATIONS LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2021-12-30 WO disclosed
WO-2020247241-A1 LOW TEMPERATURE DIVERSION IN WELL COMPLETION OPERATIONS USING A LANGBEINITE COMPOUND LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2020-12-10 WO disclosed
US-20200385627-A1 LOW TEMPERATURE DIVERSION IN WELL COMPLETION OPERATIONS USING NATURAL MINERAL COMPOUND LYONDELLBASELL ADVANCED POLYMERS INC. (US) 2020-12-10 US disclosed
EP-2542642-B1 CLEAN VISCOSIFIED TREATMENT FLUIDS AND ASSOCIATED METHODS HALLIBURTON ENERGY SERVICES INC (US) 2016-06-15 EP disclosed
US-8960290-B2 Method for delayedly crosslinking environmentally friendly fluids HALLIBURTON ENERGY SERVICES, INC. (US) 2015-02-24 US disclosed
EP-2794807-A1 METHOD FOR DELAYEDLY CROSSLINKING ENVIRONMENTALLY FRIENDLY FLUIDS Halliburton Energy Services, Inc. (US) 2014-10-29 EP disclosed
US-20120138303-A1 Methods of Providing Fluid Loss Control or Diversion HALLIBURTON ENERGY SERVICES, INC. (US) 2012-06-07 US disclosed
WO-2012072985-A1 METHODS OF PROVIDING FLUID LOSS CONTROL OR DIVERSION HALLIBURTON ENERGY SERVICES, INC. (US) 2012-06-07 WO disclosed
WO-2011107759-A1 CLEAN VISCOSIFIED TREATMENT FLUIDS AND ASSOCIATED METHODS HALLIBURTON ENERGY SERVICES INC. (US) 2011-09-09 WO disclosed
WO-2011107757-A1 CLEAN VISCOSIFIED TREATMENT FLUIDS AND ASSOCIATED METHODS HALLIBURTON ENERGY SERVICES, INC. (US) 2011-09-09 WO disclosed
WO-2011107758-A1 CLEAN VISCOSIFIED TREATMENT FLUIDS AND ASSOCIATED METHODS HALLIBURTON ENERGY SERVICES, INC. (US) 2011-09-09 WO disclosed
US-20110214868-A1 Clean Viscosified Treatment Fluids and Associated Methods HALLIBURTON ENERGY SERVICES, INC. 2011-09-08 US disclosed
US-20110214859-A1 Clean Viscosified Treatment Fluids and Associated Methods HALLIBURTON ENERGY SERVICES, INC. 2011-09-08 US disclosed
US-20110214860-A1 Clean Viscosified Treatment Fluids and Associated Methods HALLIBURTON ENERGY SERVICES, INC. 2011-09-08 US disclosed
US-4624795-A Aqueous acid gels and use thereof BJ-TITAN SERVICES COMPANY (US) 1986-11-25 US disclosed
US-4604218-A CROSSLINKABLE COPOLYMER OF DIALLYL DIALKYL AMMONIUM HALIDE AND VINLPHOSPHONIC ACID DERIVATIVES BJ-TITAN SERVICES COMPANY (US) 1986-08-05 US disclosed