Citric Acid

Citric Acid

SCHEMBL653301

CC(O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.38
ALDH1A1 P00352 2/20 0.68
TP53 P04637 1/20 0.50
CPT2 P23786 1/20 0.48
ACLY P53396 1/20 0.48
TSHR P16473 2/20 0.44
MAPT P10636 2/20 0.44
KDM4E B2RXH2 2/20 0.44
LMNA P02545 2/20 0.44
ALOX15 P16050 1/20 0.44
HMGCR P04035 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
ADRA1A P35348 1/20 0.42
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
SLC13A5 Q86YT5 4/20 0.39
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL27588805 1.00 ALDH1A1 (0.68) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL2394724 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL3880785 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL2879372 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL17686702 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL25376180 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL9387453 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL7125976 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL20521417 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR
Citric Acid SCHEMBL5048408 0.98 ALDH1A1 (0.65) ALDH1A1TP53CPT2ACLYTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 207 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4030921-B1 WHEY-BASED NUTRITIONAL COMPOSITIONS FORTIFIED WITH CALCIUM NESTLE SA (CH) 2024-02-21 EP claimed
CN-106999313-A Chemiluminescent wetness indicator for absorbent products 国际纸业公司 2017-08-01 CN claimed
CN-106608912-A Aliphatic-dicarboxylic-acid-coupled EPO mimic peptide derivative and preparation method and application thereof 天津药物研究院有限公司 2017-05-03 CN claimed
CN-104232503-B Bacillus shacheensis and application thereof 四川大学 2017-01-25 CN claimed
US-20160374352-A1 BOTANICAL ANTIMICROBIAL COMPOSITIONS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2016-12-29 US claimed
CN-106139202-A Biological deodorization preparation method of 西安永成电子科技有限责任公司 2016-11-23 CN claimed
US-20160109776-A1 Metal Sensitized Color Changing Material UNIVERSITY OF SOUTH FLORIDA (US) 2016-04-21 US claimed
CN-103726036-A Environment-friendly high-brightness medium-phosphorus chemical nickel-plating additive HARBIN SAN YONG GONG DA SCIENCE AND TECHNOLOGY CO LTD 2014-04-16 CN claimed
US-20100324137-A1 LAURIC ARGINATE AS A CONTACT ANTIMICROBIAL DIVERSEY, INC. (US) 2010-12-23 US claimed
US-7319032-B2 Non-sugar sweeteners for use in test devices MEDTOX (US) 2008-01-15 US claimed
US-20060210480-A1 Treatment of reduction of dysphagia UNIVERSITY OF MANCHESTER, THE (GB) 2006-09-21 US claimed
WO-2006064520-A1 STABLE CONCENTRATED ANTI-BACTERIAL EMULSIONS OF MONOCAPRIN IN WATER THORMAR HALLDOR (IS) 2006-06-22 WO claimed
CN-1698617-A Doxofylline freeze-dried powder injection for injection DUAN YAJUN (CN) 2005-11-23 CN claimed
EP-1198179-A1 ANTIMICROBIAL POLYPHOSPHATES IN FOOD PROCESSING ASTARIS LLC (US) 2002-04-24 EP claimed
EP-1017770-A4 AQUEOUS RINSING COMPOSITION ARCH SPEC CHEM INC (US) 2002-04-24 EP claimed
WO-2001006862-A1 ANTIMICROBIAL POLYPHOSPHATES IN FOOD PROCESSING ASTARIS LLC (US) 2001-02-01 WO claimed
US-6123973-A BY EXPOSING A SPECIFIED ANTIMICROBIAL PRODUCT SUCH AS SODIUM BENZOATE, OR POTASSIUM PROPIONATE CONTAINING A SMALL AMOUNT OF FREE ACIDS TO AMMONIA GAS TO OCNVERT THE FREE ACIDS INTO AMMONIOUM SALTS, MINIMIZING UNDESIRABLE FLAVORS OR ODORS TILLIN, INC. (US) 2000-09-26 US claimed
EP-1017770-A1 AQUEOUS RINSING COMPOSITION ARCH SPECIALTY CHEMICALS, INC. (US) 2000-07-12 EP claimed
WO-1999015609-A1 AQUEOUS RINSING COMPOSITION ARCH SPECIALTY CHEMICALS, INC. (US) 1999-04-01 WO claimed
US-5700452-A CROSSLINKED CATIONIC POLYMER; QUATERNARY AMMONIUM SALT THE PROCTER & GAMBLE COMPANY (US) 1997-12-23 US claimed