Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE8A | O60658 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | PDE8B | O95263 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21918497 | 0.88 | PDE2A (0.45) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL12759645 | 0.85 | PDE3B (0.49) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL21917606 | 0.80 | PDE3B (0.38) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL21918453 | 0.80 | KDM4E (0.39) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL24292162 | 0.80 | LIMK1 (0.35) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL24291290 | 0.78 | ACHE (0.36) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL24290405 | 0.77 | KMT2A (0.37) | NPC1KDM4ELMNAMAPTHTT | |
| SCHEMBL21298163 | 0.77 | PDE3B (0.42) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL21918445 | 0.77 | PDE2A (0.42) | PDE2APDE6DPDE8APDE5APDE9A | |
| SCHEMBL24290418 | 0.75 | MEN1 (0.35) | PDE2APDE6DPDE8APDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323963-A1 | Functional Materials Based on Stable Chemical Structure | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323963-A1 | Functional Materials Based on Stable Chemical Structure | TEAD4, TEAD2, TEAD1 | PDE2A 1972/4885PDE6D 87/4885PDE8A 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.