SCHEMBL23948423

SCHEMBL23948423

CC1(C(=O)NCc2ccncc2)CC2CC(C1)CC(C)(c1ccc(Cl)cc1)C2

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SPHK2 Q9NRA0 3/20 0.64
ALDH1A1 P00352 4/20 0.55
CYP17A1 P05093 1/20 0.55
CYP19A1 P11511 1/20 0.55
MAPT P10636 2/20 0.49
P2RX7 Q99572 1/20 0.48
SMN1; SMN2 Q16637 4/20 0.47
NAMPT P43490 2/20 0.47
HSD11B1 P28845 1/20 0.47
HSD11B2 P80365 1/20 0.47
SPHK1 Q9NYA1 1/20 0.45
HTT P42858 2/20 0.45
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.45
ALOX12 P18054 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
GRM5 P41594 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23948422 0.81 SPHK2 (0.68) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
Abc-294640 SCHEMBL31060730 0.78 SPHK2 (1.00) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
Abc-294640 SCHEMBL21116115 0.78 SPHK2 (1.00) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
Abc-294640 SCHEMBL20592375 0.78 SPHK2 (1.00) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
Abc-294640 SCHEMBL1548333 0.78 SPHK2 (1.00) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
Abc-294640 SCHEMBL29376156 0.77 SPHK2 (0.98) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
SCHEMBL4966175 0.74 SMN1; SMN2 (0.68) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
SCHEMBL29375651 0.72 ALDH1A1 (0.59) SPHK2ALDH1A1CYP17A1CYP19A1MAPT
SCHEMBL1548224 0.72 CYP17A1 (1.00) SPHK2ALDH1A1CYP17A1CYP19A1P2RX7
SCHEMBL24064926 0.71 SPHK2 (0.80) SPHK2ALDH1A1CYP17A1CYP19A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021209563-A1 COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS BY RESPIRATORY SYNDROME-RELATED CORONAVIRUS SOM INNOVATION BIOTECH, S.A. (ES) 2021-10-21 WO disclosed