Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.56 |
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22185867 | 0.85 | RAB9A (0.57) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL20932206 | 0.84 | RAB9A (0.56) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL19553943 | 0.84 | RAB9A (0.56) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL3437994 | 0.84 | HCAR3 (0.57) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL14518826 | 0.82 | NPC1 (0.53) | RAB9ANPC1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL22299570 | 0.81 | RAB9A (0.53) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL12870513 | 0.79 | POLB (0.62) | RAB9ANPC1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL11396992 | 0.76 | RAB9A (0.61) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL20665086 | 0.75 | HCAR3 (0.58) | RAB9ANPC1KDM4EHCAR3MAPT | |
| SCHEMBL7031069 | 0.75 | HCAR3 (0.58) | RAB9ANPC1KDM4EHCAR3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323922-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323922-A1 | PD-1/PD-L1 INHIBITORS | CD274, PDCD1, PDCD1LG2 | RAB9A 1946/4885NPC1 1887/4885KDM4E 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.