Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 9/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950444 | 0.87 | NLRP3 (0.69) | NLRP3NTRK1TSHRHTTSMN1; SMN2 | |
| SCHEMBL23950398 | 0.85 | NLRP3 (0.62) | NLRP3NTRK1 | |
| SCHEMBL23950434 | 0.85 | NLRP3 (0.65) | NLRP3NTRK1OPRM1OPRL1TSHR | |
| SCHEMBL23952170 | 0.83 | NLRP3 (0.64) | NLRP3NTRK1OPRM1OPRL1TSHR | |
| SCHEMBL23925592 | 0.83 | NLRP3 (0.66) | NLRP3NTRK1TSHRHTTSMN1; SMN2 | |
| SCHEMBL23950225 | 0.83 | NLRP3 (0.66) | NLRP3NTRK1OPRM1OPRL1TSHR | |
| SCHEMBL23950420 | 0.81 | NLRP3 (0.42) | NLRP3HTTFPR1FPR3FPR2 | |
| SCHEMBL23950412 | 0.80 | NLRP3 (0.49) | NLRP3OPRM1OPRL1TSHRHTT | |
| SCHEMBL23951018 | 0.80 | NLRP3 (0.62) | NLRP3NTRK1OPRM1OPRL1TSHR | |
| SCHEMBL30040340 | 0.80 | NLRP3 (0.62) | NLRP3NTRK1OPRM1OPRL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203044-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-29 | — | — | US | disclosed |
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203044-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME | NLRP3, PYCARD, NLRP1 | NLRP3 1/4885NTRK1 4081/4885OPRM1 4490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.