Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 12/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950456 | 0.85 | NLRP3 (0.51) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL25243118 | 0.85 | NLRP3 (0.51) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL23950189 | 0.85 | NLRP3 (0.51) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL25753005 | 0.84 | NLRP3 (0.51) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL25751754 | 0.83 | NLRP3 (0.50) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL30149314 | 0.82 | NLRP3 (0.49) | NLRP3KCNH2CHRNA7 | |
| SCHEMBL23950971 | 0.79 | GAA (0.33) | NLRP3 | |
| SCHEMBL23950511 | 0.76 | NLRP3 (0.62) | NLRP3KCNH2 | |
| SCHEMBL23950201 | 0.74 | NLRP3 (0.35) | NLRP3 | |
| SCHEMBL23950603 | 0.73 | NLRP3 (0.66) | NLRP3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |