Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950545 | 0.87 | NLRP3 (0.44) | NLRP3THRBTP53CHRNA7CHRNA1 | |
| SCHEMBL25290583 | 0.87 | NLRP3 (0.44) | NLRP3THRBTP53CHRNA7CHRNA1 | |
| SCHEMBL23950649 | 0.76 | NLRP3 (0.46) | NLRP3THRBTP53CHRNA7CHRNA1 | |
| SCHEMBL23950530 | 0.74 | NLRP3 (0.44) | NLRP3THRBTP53CHRNA7 | |
| SCHEMBL23950527 | 0.74 | NLRP3 (0.44) | NLRP3THRBTP53CHRNA7 | |
| SCHEMBL23950795 | 0.72 | NLRP3 (0.41) | NLRP3THRBTP53KMT2A | |
| SCHEMBL23950819 | 0.71 | THRB (0.48) | NLRP3THRBTP53CHRNA7CHRNA1 | |
| SCHEMBL23950360 | 0.70 | NLRP3 (0.58) | NLRP3THRBTP53 | |
| SCHEMBL25754562 | 0.69 | NLRP3 (0.47) | NLRP3THRBTP53CHRNA7CHRNA1 | |
| SCHEMBL23950798 | 0.68 | NLRP3 (0.38) | NLRP3TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021209552-A1 | PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |