Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23952190 | 0.88 | NLRP3 (0.41) | NLRP3MAPTKMT2ARXFP1THRB | |
| SCHEMBL23952607 | 0.86 | NLRP3 (0.41) | NLRP3MAPTRXFP1PTGER1CMA1 | |
| SCHEMBL23952028 | 0.84 | NLRP3 (0.43) | NLRP3MAPTRXFP1PTGER1CMA1 | |
| SCHEMBL25819084 | 0.82 | NLRP3 (0.40) | NLRP3S1PR1 | |
| SCHEMBL23952175 | 0.82 | NLRP3 (0.57) | NLRP3MAPTRXFP1 | |
| SCHEMBL23952591 | 0.77 | NLRP3 (0.55) | NLRP3PTGER1CMA1LMNA | |
| SCHEMBL23952443 | 0.75 | KDM4E (0.41) | NLRP3MAPTKMT2ARXFP1MEN1 | |
| SCHEMBL28970048 | 0.75 | NLRP3 (0.44) | NLRP3PTGER1CMA1LMNA | |
| SCHEMBL23952196 | 0.74 | NLRP3 (0.49) | NLRP3MAPTKMT2ARXFP1THRB | |
| SCHEMBL23952023 | 0.73 | NLRP3 (0.43) | NLRP3MAPTPTGER1CMA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | disclosed |
| WO-2021209539-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | NLRP3, NLRP1, IL1B | NLRP3 1/4885MAPT 1978/4885S1PR1 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.