Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 8/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27325954 | 0.91 | KDM4E (0.61) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL20169884 | 0.90 | CYP3A4 (0.61) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL28565701 | 0.87 | ABCG2 (0.69) | KDM4EKMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL27491848 | 0.86 | KDM4E (0.66) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL27325970 | 0.86 | KDM4E (0.62) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL17523229 | 0.86 | MAPT (0.61) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL2397393 | 0.84 | MAPT (0.75) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL16151142 | 0.84 | BCHE (0.56) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL10769734 | 0.84 | ABCG2 (0.72) | KDM4ECYP3A4MEN1KMT2AHSD17B10 | |
| SCHEMBL23259577 | 0.82 | KDM4E (0.67) | KDM4ECYP3A4MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017649-B2 | Flavonoid compounds and uses thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2011-09-13 | — | — | US | disclosed |
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | disclosed |
| EP-1856085-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | Howard Florey Institute of Experimental Physiology and Medicine (AU) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094357-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2006-09-14 | — | — | WO | disclosed |
| EP-0233105-A1 | Therapeutical compositions based on 3-alkoxyflavone derivatives and derivatives of 3-alkoxyflavones | INSTITUT PASTEUR (FR) | 1987-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | CAT, NQO1, GPX4 | KDM4E 4144/4885CYP3A4 518/4885MEN1 4830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.