SCHEMBL23957802

SCHEMBL23957802

C[C@H](N[S+]([O-])C(C)(C)C)c1ccc(-n2cc(Cl)cn2)nc1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 3/20 0.37
P2RX3 P56373 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28938110 1.00 EGLN1 (0.37) EGLN1P2RX3
SCHEMBL23957695 0.87 EGLN1 (0.36) EGLN1P2RX3
SCHEMBL30175356 0.87 EGLN1 (0.36) EGLN1P2RX3
SCHEMBL17966632 0.86 RET (0.38) EGLN1
SCHEMBL17966631 0.86 RET (0.38) EGLN1
SCHEMBL18821888 0.86 RET (0.38) EGLN1
SCHEMBL23929889 0.86 RET (0.38) EGLN1
SCHEMBL23957787 0.86 RET (0.38) EGLN1
SCHEMBL18806642 0.86 RET (0.38) EGLN1
SCHEMBL29521133 0.86 RET (0.38) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115605477-B Pyrazolo [1,5-a ] pyridine derivative, preparation method, composition and application thereof 深圳众格生物科技有限公司 2024-07-05 CN disclosed
US-20230159523-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD. (CN) 2023-05-25 US disclosed
US-20230159523-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD. (CN) 2023-05-25 US disclosed
EP-4141003-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF Shenzhen Zhongge Biological Technology Co., Ltd. (CN) 2023-03-01 EP disclosed
CN-115605477-A Pyrazolo [1,5-a ] pyridine derivative and preparation method, composition and application thereof 深圳众格生物科技有限公司(CN) 2023-01-13 CN disclosed
WO-2021213476-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF 深圳晶泰科技有限公司 (CN) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159523-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF NCOA4, CCDC47, CCDC6 EGLN1 3833/4885P2RX3 3132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.