⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323305 | 0.86 | ALDH1A1 (0.72) | — | |
| SCHEMBL7321598 | 0.85 | ALDH1A1 (0.76) | — | |
| SCHEMBL11312893 | 0.80 | — | — | |
| SCHEMBL14977428 | 0.80 | ALDH1A1 (0.86) | — | |
| SCHEMBL11733425 | 0.79 | POLB (0.42) | — | |
| SCHEMBL15709879 | 0.78 | ALDH1A1 (1.00) | — | |
| SCHEMBL14986945 | 0.78 | ALDH1A1 (1.00) | — | |
| SCHEMBL2208668 | 0.78 | — | — | |
| SCHEMBL11233890 | 0.76 | — | — | |
| SCHEMBL7161882 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10206937-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170136047-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136047-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| WO-2016003929-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2016-01-07 | — | — | WO | disclosed |
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2006-07-06 | — | — | US | disclosed |
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |
| EP-0592453-B1 | AMINOALKYL-SUBSTITUTED 2-AMINO-1,3,4-THIADIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AG (DE) | 1998-12-16 | — | — | EP | disclosed |
| US-3990882-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | disclosed |
| US-3988143-A | 1-Thiadiazolyl-6-alkoxytetrahydropyrimidinones | VELSICOL CHEMICAL CORPORATION (US) | 1976-10-26 | — | — | US | disclosed |
| US-3979388-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-09-07 | — | — | US | disclosed |
| US-3951976-A | 1-Thiadiazoly-6-carbamoyloxytetrahydropyrimidinones | VELSICOL CHEMICAL CORPORATION (US) | 1976-04-20 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |
| US-3944409-A | Method of increasing the yield of plants having storage organs by treatment with thiadiazolylimidazolines | VELSICOL CHEMICAL CORPORATION (US) | 1976-03-16 | — | — | US | disclosed |
| US-3933839-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |
| US-3932410-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-01-13 | — | — | US | disclosed |
| US-3931209-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-01-06 | — | — | US | disclosed |