Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18357966 | 0.77 | PDK2 (0.36) | KDM4EALDH1A1GAAHPGDMAPK1 | |
| SCHEMBL20247408 | 0.74 | MAPK1 (0.33) | MAPK1PDPK1 | |
| SCHEMBL3954043 | 0.74 | MAPK1 (0.44) | MAPK1PDPK1 | |
| SCHEMBL3950985 | 0.70 | PDPK1 (0.38) | MAPK1PDPK1 | |
| SCHEMBL24659878 | 0.69 | CYP1A2 (0.33) | MAPT | |
| SCHEMBL19260963 | 0.69 | JAK2 (0.43) | MAPK1 | |
| SCHEMBL24121832 | 0.66 | PDPK1 (0.35) | KDM4EGAAMAPK1PDPK1 | |
| SCHEMBL23229339 | 0.65 | DYRK1A (0.36) | PDPK1 | |
| SCHEMBL13210046 | 0.64 | MEN1 (0.35) | HPGDLMNA | |
| SCHEMBL23169547 | 0.63 | ALDH1A1 (0.37) | ALDH1A1MAPK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021213317-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 微境生物医药科技(上海)有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |