SCHEMBL23964264

SCHEMBL23964264

Clc1cccc2cc(CN3CCN(c4ccncc4)CC3)[nH]c12

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 3/20 0.45
DRD4 P21917 10/20 0.43
DRD2 P14416 8/20 0.43
DRD3 P35462 8/20 0.43
HTT P42858 1/20 0.42
HRH1 P35367 2/20 0.41
HRH3 Q9Y5N1 2/20 0.41
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
ACHE P22303 1/20 0.40
HRH2 P25021 1/20 0.40
HRH4 Q9H3N8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30040821 1.00 KDM4E (0.45) KDM4EALDH1A1DRD4DRD2DRD3
SCHEMBL23964149 0.81 KDM4E (0.45) KDM4EALDH1A1DRD4DRD2DRD3
SCHEMBL30041451 0.80 HRH4 (0.63) DRD4DRD2DRD3HRH1HRH3
SCHEMBL23964200 0.80 HRH4 (0.63) DRD4DRD2DRD3HRH1HRH3
SCHEMBL30040776 0.78 DRD4 (0.61) ALDH1A1DRD4DRD2DRD3HRH1
SCHEMBL23964191 0.78 DRD4 (0.61) ALDH1A1DRD4DRD2DRD3HRH1
SCHEMBL30041336 0.77 DRD4 (0.55) DRD4DRD2DRD3ACHEHRH4
SCHEMBL23964261 0.77 DRD4 (0.64) DRD4DRD2DRD3HRH1HRH3
SCHEMBL23932491 0.77 DRD4 (0.55) DRD4DRD2DRD3ACHEHRH4
SCHEMBL23964212 0.76 HRH4 (0.57) DRD4DRD2DRD3HRH1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
CN-115427404-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-12-02 CN disclosed
WO-2021216665-A9 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-12-02 WO disclosed
WO-2021216665-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF COL1A1, COL2A1, COL14A1 KDM4E 1980/4885ALDH1A1 1196/4885DRD4 4746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.