Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.33 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isocitric Acid SCHEMBL29645996 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitric Acid SCHEMBL2794437 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitric Acid SCHEMBL27894954 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitrate SCHEMBL1289944 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitric Acid SCHEMBL12927570 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitric Acid SCHEMBL6249818 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitrate SCHEMBL8373 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitric Acid SCHEMBL30700829 | 0.97 | TDP1 (0.68) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitrate SCHEMBL23648394 | 0.95 | TDP1 (0.65) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 | |
| Isocitrate SCHEMBL2580646 | 0.95 | TDP1 (0.74) | TDP1SMN1; SMN2SLC22A6TSHRGABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563538-B2 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2013-10-22 | — | — | US | claimed |
| EP-1487431-B1 | PREVENTING AND/OR TREATING CARDIOVASCULAR DISEASE AND/OR ASSOCIATED HEART FAILURE | PHILERA NEW ZEALAND LTD (NZ) | 2012-05-02 | — | — | EP | claimed |
| US-8034799-B2 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2011-10-11 | — | — | US | claimed |
| US-20110212188-A1 | PREVENTING AND/OR TREATING CARDIOVASCULAR DISEASE AND/OR ASSOCIATED HEART FAILURE | PHILERA NEW ZEALAND LIMITED (NZ) | 2011-09-01 | — | — | US | claimed |
| US-20060009534-A1 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2006-01-12 | — | — | US | claimed |