Isocitric Acid

Isocitric Acid

SCHEMBL29645996

O=C(O)C[C@@H](C(=O)O)[C@@H](O)C(=O)O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.68
SMN1; SMN2 Q16637 1/20 0.50
SLC22A6 Q4U2R8 1/20 0.48
TSHR P16473 2/20 0.47
GABRR1 P24046 2/20 0.40
LMNA P02545 1/20 0.40
CYP2C9 P11712 1/20 0.37
PDE4A P27815 1/20 0.37
FOLH1 Q04609 1/20 0.37
MAPT P10636 1/20 0.36
TET2 Q6N021 3/20 0.35
KDM4A O75164 2/20 0.35
KDM4C Q9H3R0 2/20 0.35
KDM2A Q9Y2K7 2/20 0.35
TET3 O43151 1/20 0.35
CPT2 P23786 1/20 0.34
ACLY P53396 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isocitric Acid SCHEMBL27894954 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitric Acid SCHEMBL30700829 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitric Acid SCHEMBL2794437 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitric Acid SCHEMBL6249818 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitric Acid SCHEMBL12927570 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitrate SCHEMBL1289944 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitrate SCHEMBL8373 1.00 TDP1 (0.68) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitrate SCHEMBL23648394 0.97 TDP1 (0.65) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitrate SCHEMBL2580646 0.97 TDP1 (0.74) TDP1SMN1; SMN2SLC22A6TSHRGABRR1
Isocitrate SCHEMBL2396434 0.97 TDP1 (0.65) TDP1SMN1; SMN2SLC22A6TSHRGABRR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240299495-A1 STABILIZED AFGF COMPOSITIONS Eusol Biotech Co., Ltd. (TW) 2024-09-12 US disclosed
US-20220152153-A1 STABILIZED AFGF COMPOSITIONS Eusol Biotech Co., Ltd. (TW) 2022-05-19 US disclosed
WO-2022100643-A1 STABILIZED AFGF COMPOSITIONS Eusol Biotech Co., Ltd. (CN) 2022-05-19 WO disclosed