Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 15/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23964783 | 0.92 | MEN1 (0.50) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL23964663 | 0.88 | MEN1 (0.50) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL22213296 | 0.84 | KMT2A (0.54) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20769500 | 0.70 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20769507 | 0.67 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL29901429 | 0.66 | KMT2A (0.48) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| Bromide SCHEMBL29901483 | 0.66 | KMT2A (0.48) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20769501 | 0.61 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL29694300 | 0.61 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL14977955 | 0.61 | KDM4E (0.63) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3680243-B1 | PENTACYCLIC COMPOUND | EISAI R&D MAN CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |