Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 16/20 | 0.54 |
| ▸ | MEN1 | O00255 | 13/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23964640 | 0.84 | MEN1 (0.50) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL23964663 | 0.82 | MEN1 (0.50) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL23964783 | 0.77 | MEN1 (0.50) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL20769501 | 0.71 | KMT2A (0.49) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL29694300 | 0.71 | KMT2A (0.49) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6034967 | 0.65 | TGM2 (0.70) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL23964784 | 0.64 | MKNK1 (0.36) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6033436 | 0.64 | KMT2A (0.77) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6034970 | 0.62 | TGM2 (1.00) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6987974 | 0.61 | HTR1A (0.81) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3680243-B1 | PENTACYCLIC COMPOUND | EISAI R&D MAN CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3680243-A1 | PENTACYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2020-07-15 | — | — | EP | disclosed |