Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396976 | 0.80 | PIK3CG (0.49) | DYRK1AIRAK4ITKLCKAURKB | |
| SCHEMBL2396989 | 0.80 | PIK3CG (0.49) | DYRK1AIRAK4ITKLCKAURKB | |
| Trifluoroacetic Acid SCHEMBL2370610 | 0.79 | IRAK4 (0.41) | DYRK1AIRAK4ITKLCKAURKB | |
| SCHEMBL2397731 | 0.78 | ITK (0.50) | IRAK4CCNT1ITKLCKAURKB | |
| SCHEMBL2397725 | 0.78 | ITK (0.50) | IRAK4CCNT1ITKLCKAURKB | |
| SCHEMBL2395088 | 0.76 | ITK (0.43) | DYRK1AIRAK4CCNT1ITKPIK3CA | |
| SCHEMBL2395099 | 0.76 | ITK (0.43) | DYRK1AIRAK4CCNT1ITKPIK3CA | |
| SCHEMBL2397615 | 0.74 | ITK (0.39) | CCNT1ITKLCKAURKB | |
| SCHEMBL2370617 | 0.73 | IRAK4 (0.39) | IRAK4ITKLCKAURKBCDK2 | |
| SCHEMBL2370612 | 0.73 | IRAK4 (0.39) | IRAK4ITKLCKAURKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |