Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30738512 | 0.81 | LMNA (0.43) | MAP4K4LMNAUSP2CYP1A2CYP3A4 | |
| SCHEMBL22179969 | 0.81 | LMNA (0.43) | MAP4K4LMNAUSP2CYP1A2CYP3A4 | |
| SCHEMBL22179952 | 0.74 | NAMPT (0.41) | LMNAMAPK14USP2CYP1A2CYP3A4 | |
| SCHEMBL21621299 | 0.73 | ADORA1 (0.46) | MAP4K4ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL30738319 | 0.72 | ADORA2A (0.59) | MAP4K4ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL20392686 | 0.72 | ADORA2A (0.59) | MAP4K4ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL21621174 | 0.71 | ADORA1 (0.46) | MAP4K4ADORA3ADORA2AADORA1CYP1A2 | |
| SCHEMBL21621285 | 0.69 | MAP4K4 (0.46) | MAP4K4ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL29947049 | 0.69 | MAP4K4 (0.46) | MAP4K4ADORA3ADORA2AADORA1LMNA | |
| SCHEMBL21621282 | 0.69 | NUDT1 (0.44) | MAP4K4ADORA2AADORA1LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904352-A1 | SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2021-11-03 | — | — | EP | disclosed |