Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 8/20 | 0.43 |
| ▸ | LCK | P06239 | 6/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396602 | 1.00 | ABL1 (0.46) | ABL1PIK3CGITKLCKAURKB | |
| Trifluoroacetic Acid SCHEMBL2396596 | 0.87 | ITK (0.53) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL2396683 | 0.83 | ITK (0.57) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL2396679 | 0.83 | ITK (0.57) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL140132 | 0.76 | LCK (0.59) | PIK3CGITKLCKAURKBEGFR | |
| SCHEMBL2370102 | 0.76 | ITK (0.51) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL2370095 | 0.76 | ITK (0.51) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL2396582 | 0.74 | PIK3CD (0.46) | ABL1PIK3CGITKLCKAURKB | |
| SCHEMBL144766 | 0.74 | AURKB (0.58) | ABL1ITKLCKAURKBEGFR | |
| SCHEMBL144767 | 0.74 | AURKB (0.58) | ABL1ITKLCKAURKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |