Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263983 | 0.78 | HRH3 (0.49) | KCNH2LMNAALDH1A1HRH3MAPT | |
| SCHEMBL13499613 | 0.78 | HRH3 (0.43) | KCNH2LMNAGAAALDH1A1HRH3 | |
| SCHEMBL12367362 | 0.77 | KCNH2 (0.50) | KCNH2LMNAGAAALDH1A1HRH3 | |
| SCHEMBL18033543 | 0.75 | HRH3 (0.52) | KCNH2ALDH1A1HRH3DPP8DPP9 | |
| SCHEMBL2625792 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HSD17B10NOTUMKMT2AAADAT | |
| SCHEMBL21008360 | 0.71 | ALDH1A1 (0.37) | LMNAGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL5022141 | 0.70 | NOTUM (0.43) | LMNAGAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL18033537 | 0.70 | HRH3 (0.50) | KCNH2LMNAGAAALDH1A1HRH3 | |
| SCHEMBL2616323 | 0.70 | ALDH1A1 (0.60) | GAAALDH1A1MAPTNOTUMMEN1 | |
| SCHEMBL23774907 | 0.70 | RIPK1 (0.40) | KCNH2LMNAGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353164-B1 | BI-HETEROARYL SUBSTITUTED 1,4-BENZODIAZEPINES AND USES THEREOF FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-03 | — | — | EP | disclosed |