Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28377237 | 0.87 | ALOX15 (0.56) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23909042 | 0.86 | TSHR (0.55) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23909061 | 0.85 | ALOX15 (0.53) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23909094 | 0.84 | MAPT (0.64) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23915567 | 0.81 | LMNA (0.64) | TSHRRAB9AGAAPOLB | |
| SCHEMBL30711161 | 0.74 | SLC16A3 (0.48) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18171832 | 0.73 | KDM4E (0.48) | TSHRMAPTPOLBALDH1A1 | |
| SCHEMBL23909132 | 0.73 | KDM4E (0.45) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23915394 | 0.72 | RECQL (0.56) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23909083 | 0.72 | KDM4E (0.51) | CYP1A2CYP3A4CYP2C9CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |