Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009486 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL13775156 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL9234683 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL23908897 | 0.79 | CA1 (0.40) | ALDH1A1KMT2AMEN1HSD17B10TDP1 | |
| SCHEMBL23966494 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTKMT2AMEN1GLA | |
| SCHEMBL23914627 | 0.74 | MAPK1 (0.38) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL23966517 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL9674944 | 0.71 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL9674953 | 0.71 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1HSD17B10 | |
| SCHEMBL24662339 | 0.69 | CTDSP1 (0.43) | ALDH1A1MAPTKMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |
| CN-110869359-A | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis | 加拉帕戈斯股份有限公司 | 2020-03-06 | — | — | CN | disclosed |