Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | G6PD | P11413 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.36 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914596 | 0.87 | KDM4E (0.40) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL23915452 | 0.81 | MAPT (0.43) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL3288183 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL6052133 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL16668336 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL311969 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL3746625 | 0.78 | FFAR1 (0.49) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL5186627 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL20108197 | 0.77 | AAK1 (0.44) | ALDH1A1MAPTKDM4EUSP2MEN1 | |
| SCHEMBL18122079 | 0.77 | AR (0.52) | ALDH1A1MAPTKDM4EUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |