Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 8/20 | 0.50 |
| ▸ | GPR39 | O43194 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966559 | 0.92 | GPR39 (0.50) | MAPTGPR39KMT2AHRH1S1PR2 | |
| SCHEMBL23966556 | 0.91 | MAPT (0.58) | MAPTAKR1B1GPR39KMT2AHRH1 | |
| SCHEMBL23913676 | 0.89 | MAPT (0.53) | MAPTAKR1B1GPR39KMT2AHRH1 | |
| SCHEMBL23915524 | 0.85 | MAPT (0.67) | MAPTAKR1B1GPR39KMT2APOLB | |
| SCHEMBL23966558 | 0.85 | RECQL (0.57) | MAPTGPR39HRH1ALDH1A1NPSR1 | |
| SCHEMBL23915443 | 0.83 | MAPT (0.51) | MAPTAKR1B1GPR39KMT2AHRH1 | |
| SCHEMBL23915515 | 0.83 | NPC1 (0.49) | MAPTGPR39KMT2AHRH1ADRA1A | |
| SCHEMBL23913685 | 0.83 | MAPT (0.64) | MAPTAKR1B1GPR39KMT2AHRH1 | |
| SCHEMBL23914889 | 0.81 | RECQL (0.56) | MAPTAKR1B1GPR39HRH1S1PR2 | |
| SCHEMBL23915614 | 0.79 | GPR39 (0.62) | MAPTGPR39HRH1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |