Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR39 | O43194 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966559 | 0.93 | GPR39 (0.50) | RECQLNPSR1ALDH1A1SMN1; SMN2GPR39 | |
| SCHEMBL23966556 | 0.90 | MAPT (0.58) | RECQLNPSR1ALDH1A1SMN1; SMN2GPR39 | |
| SCHEMBL23915515 | 0.89 | NPC1 (0.49) | RECQLNPSR1ALDH1A1SMN1; SMN2GPR39 | |
| SCHEMBL23914889 | 0.88 | RECQL (0.56) | RECQLALDH1A1SMN1; SMN2GPR39L3MBTL1 | |
| SCHEMBL23915614 | 0.85 | GPR39 (0.62) | RECQLALDH1A1SMN1; SMN2GPR39L3MBTL1 | |
| SCHEMBL23966557 | 0.85 | MAPT (0.56) | NPSR1ALDH1A1GPR39HRH1MAPT | |
| SCHEMBL23915513 | 0.83 | NPC1 (0.46) | RECQLNPSR1ALDH1A1SMN1; SMN2GPR39 | |
| SCHEMBL23914890 | 0.80 | HRH1 (0.55) | RECQLALDH1A1SMN1; SMN2GPR39L3MBTL1 | |
| SCHEMBL23913676 | 0.78 | MAPT (0.53) | ALDH1A1SMN1; SMN2GPR39HRH1MAPT | |
| SCHEMBL23915623 | 0.78 | RECQL (0.47) | RECQLALDH1A1SMN1; SMN2GPR39SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |