Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23154562 | 0.81 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL11436726 | 0.80 | MAPT (0.48) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL6371564 | 0.78 | GAA (0.55) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL22359521 | 0.78 | MAPT (0.41) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL22359420 | 0.76 | L3MBTL1 (0.44) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL18835661 | 0.75 | KDM4E (0.46) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL25658779 | 0.74 | NPC1 (0.61) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL6814560 | 0.74 | GAA (0.71) | ALDH1A1MAPTL3MBTL1HPGDKDM4E | |
| SCHEMBL18534459 | 0.73 | GAA (0.46) | ALDH1A1MAPK1TSHRGAA | |
| SCHEMBL8780081 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |