Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | LITAF | Q99732 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 3/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23909091 | 0.87 | BTK (0.34) | BTKS1PR2PIK3CDTNFLITAF | |
| SCHEMBL23915581 | 0.84 | S1PR2 (0.49) | BTKS1PR2PIK3CDTNFLITAF | |
| SCHEMBL23966551 | 0.84 | S1PR2 (0.37) | S1PR2 | |
| SCHEMBL23966827 | 0.83 | S1PR2 (0.36) | S1PR2PIK3CD | |
| SCHEMBL23915420 | 0.81 | S1PR2 (0.33) | S1PR2 | |
| SCHEMBL23915477 | 0.79 | S1PR2 (0.52) | S1PR2NSD2TBK1PARP1 | |
| SCHEMBL23966578 | 0.77 | S1PR2 (0.44) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23966577 | 0.77 | S1PR2 (0.38) | S1PR2 | |
| SCHEMBL23914857 | 0.76 | S1PR2 (0.43) | BTKS1PR2PIK3CDTNFLITAF | |
| SCHEMBL23915604 | 0.75 | ADRA1A (0.37) | S1PR2ADRA1AHRH1ADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |