Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 10/20 | 0.58 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23908950 | 0.88 | S1PR2 (0.70) | S1PR2RHEBMEN1USP2MAPT | |
| SCHEMBL23914869 | 0.78 | S1PR2 (0.72) | S1PR2RHEBMEN1KMT2APIK3CD | |
| SCHEMBL23908734 | 0.77 | S1PR2 (0.69) | S1PR2RHEBUSP2 | |
| SCHEMBL23908755 | 0.76 | S1PR2 (0.68) | S1PR2RHEBALDH1A1MEN1KMT2A | |
| SCHEMBL23908842 | 0.76 | S1PR2 (0.79) | S1PR2SMN1; SMN2KDM4EMEN1MAPT | |
| SCHEMBL23908835 | 0.75 | S1PR2 (0.66) | S1PR2RHEBSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL23908996 | 0.74 | S1PR2 (0.67) | S1PR2RHEBALDH1A1MEN1KMT2A | |
| SCHEMBL23908918 | 0.74 | S1PR2 (0.69) | S1PR2RHEB | |
| SCHEMBL23966552 | 0.74 | S1PR2 (0.84) | S1PR2RHEB | |
| SCHEMBL23966848 | 0.73 | S1PR2 (0.72) | S1PR2RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |