Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105411 | 0.88 | MAPT (0.75) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10035910 | 0.86 | MAPT (0.80) | CYP3A4CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL21855141 | 0.84 | MAPT (0.54) | CYP2C19MAPK1MEN1KMT2AMAPT | |
| SCHEMBL18812853 | 0.82 | ALDH1A1 (0.64) | CYP3A4CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL23126532 | 0.81 | CYP3A4 (0.74) | CYP3A4CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL30985057 | 0.81 | POLB (0.51) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL30984960 | 0.80 | MAPT (0.72) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL13247587 | 0.79 | SIRT6 (0.73) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL21526639 | 0.79 | SIRT6 (0.52) | CYP3A4CYP2C19MAPK1HIF1AMAPT | |
| SCHEMBL30984732 | 0.79 | MAPT (0.66) | CYP3A4CYP2C19MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572413-B1 | 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE DERIVATIVE AS WEE1 INHIBITOR | SHIJIAZHUANG SAGACITY NEW DRUG DEV CO LTD (CN) | 2021-11-03 | — | — | EP | disclosed |