Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.39 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399018 | 0.93 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTOPRM1DRD2 | |
| Fumaric Acid SCHEMBL1934763 | 0.88 | ALDH1A1 (0.40) | HRH1CXCR4ALDH1A1KDM4EMAPT | |
| Fumaric Acid SCHEMBL1937053 | 0.85 | SLC6A2 (0.45) | HRH1 | |
| Fumaric Acid SCHEMBL2396810 | 0.84 | CYP1A2 (0.42) | HRH1CXCR4ALDH1A1KDM4EMAPT | |
| Fumaric Acid SCHEMBL1936259 | 0.83 | HRH1 (0.44) | HRH1SMN1; SMN2 | |
| Fumaric Acid SCHEMBL2395183 | 0.83 | HRH1 (0.36) | HRH1CXCR4ALDH1A1KDM4EMAPT | |
| Fumaric Acid SCHEMBL1935979 | 0.82 | HRH1 (0.40) | HRH1CXCR4ALDH1A1KDM4EMAPT | |
| Fumaric Acid SCHEMBL1936654 | 0.82 | HRH1 (0.40) | HRH1CXCR4ALDH1A1KDM4EMAPT | |
| Fumaric Acid SCHEMBL1935961 | 0.81 | HRH1 (0.38) | HRH1CXCR4MAPTSMN1; SMN2DRD2 | |
| SCHEMBL2396429 | 0.81 | ALDH1A1 (0.42) | HRH1ALDH1A1KDM4ESMN1; SMN2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212997-A1 | PIPERIDINE-4-ACETAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212997-A1 | PIPERIDINE-4-ACETAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, SLC18A3 | HRH1 244/4885DRD2 32/4885CXCR4 1747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.