⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL27763610 | 0.98 | — | — | |
| Hydrochlorthiazide SCHEMBL2396773 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL28834424 | 0.84 | — | — | |
| Hydrazinecarboxamide SCHEMBL28247931 | 0.83 | CYP1A2 (0.43) | — | |
| Hydrochlorthiazide SCHEMBL28184546 | 0.82 | — | — | |
| Hydrochlorthiazide SCHEMBL10514016 | 0.78 | P2RX7 (0.33) | — | |
| Hydrochlorthiazide SCHEMBL2807097 | 0.78 | — | — | |
| Hydrochlorthiazide SCHEMBL2398484 | 0.77 | — | — | |
| Hydrochlorthiazide SCHEMBL28076623 | 0.77 | TSHR (0.32) | — | |
| Hydrochlorthiazide SCHEMBL352730 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116731006-B | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2024-04-02 | — | — | CN | claimed |
| CN-116731006-A | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2023-09-12 | — | — | CN | claimed |
| CN-116731006-B | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2024-04-02 | — | — | CN | disclosed |
| CN-116731006-B | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2024-04-02 | — | — | CN | disclosed |
| CN-116731006-B | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2024-04-02 | — | — | CN | disclosed |
| CN-116731006-A | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2023-09-12 | — | — | CN | disclosed |
| CN-116731006-A | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2023-09-12 | — | — | CN | disclosed |
| CN-116731006-A | Thiazole aminoguanidine compound as well as preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2023-09-12 | — | — | CN | disclosed |