Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551905 | 0.81 | PTGS2 (0.47) | PTGS2SCD | |
| SCHEMBL17402613 | 0.79 | PTGS2 (0.40) | PTGS2SCDPTGS1CNR1 | |
| SCHEMBL16069446 | 0.79 | PTGS2 (0.40) | PTGS2SCDCNR1 | |
| SCHEMBL16069373 | 0.78 | PTGS2 (0.40) | PTGS2SCDCNR1 | |
| SCHEMBL17402602 | 0.78 | PTGS2 (0.41) | PTGS2SCDPTGS1CNR1 | |
| SCHEMBL23967692 | 0.76 | PTGS1 (0.45) | PTGS2SCDPTGS1 | |
| SCHEMBL16069331 | 0.76 | PRKAG1 (0.47) | PTGS2SCDCNR1 | |
| SCHEMBL16069890 | 0.75 | CNR1 (0.38) | PTGS2SCDPTGS1CNR1 | |
| SCHEMBL17391613 | 0.75 | CNR1 (0.38) | PTGS2SCDPTGS1CNR1 | |
| SCHEMBL16069441 | 0.75 | PRKAG1 (0.47) | PTGS2SCDCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |