Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16011810 | 0.85 | EGFR (0.47) | LRRK2ALKMAPK14UTS2RPTK6 | |
| SCHEMBL16011815 | 0.84 | F3 (0.42) | LRRK2ALKMAPK14UTS2RPTK6 | |
| SCHEMBL23967926 | 0.81 | PTK6 (0.49) | ALKMAPK14UTS2RPTK6ERBB2 | |
| SCHEMBL16024056 | 0.81 | BRD4 (0.48) | ALKPTK6EGFR | |
| SCHEMBL16257469 | 0.81 | LRRK2 (0.53) | LRRK2ALKMAPK14UTS2RPTK6 | |
| SCHEMBL16011816 | 0.79 | GRIN2D (0.43) | LRRK2ALKMAPK14UTS2RPTK6 | |
| SCHEMBL20462095 | 0.78 | PTK6 (0.48) | LRRK2ALKMAPK14UTS2RPTK6 | |
| SCHEMBL16024047 | 0.78 | ERBB2 (0.61) | LRRK2ALKMAPK14PTK6ERBB2 | |
| SCHEMBL16011993 | 0.78 | MAPK14 (0.48) | ALKMAPK14PTK6ERBB2AURKA | |
| SCHEMBL1719623 | 0.76 | NUDT1 (0.61) | PRMT6EPHX2LRRK2ALKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189052-B1 | CAMKII INHIBITORS AND USES THEREOF | UNIV JOHNS HOPKINS (US) | 2021-11-03 | — | — | EP | disclosed |