Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23968071 | 0.89 | MLYCD (0.42) | MELKRXRAGRIN1GRIN2B | |
| SCHEMBL23968199 | 0.84 | MAPKAPK2 (0.57) | MELKMAPKAPK2 | |
| SCHEMBL23968072 | 0.83 | MELK (0.45) | MELKMAP4K1MAPKAPK2RXRAGRIN1 | |
| SCHEMBL23968001 | 0.82 | MELK (0.51) | MELK | |
| SCHEMBL23968161 | 0.82 | S1PR1 (0.41) | MELKMAP4K1 | |
| SCHEMBL23968081 | 0.81 | MELK (0.45) | MELKMAPKAPK2 | |
| SCHEMBL23968093 | 0.80 | MAP4K4 (0.54) | MELK | |
| SCHEMBL23968106 | 0.79 | MELK (0.43) | MELK | |
| SCHEMBL29266901 | 0.78 | ABL1 (0.51) | MELKMAPKAPK2RXRAGRIN1GRIN2B | |
| SCHEMBL23968168 | 0.78 | MELK (0.46) | MELKMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |