Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.51 |
| ▸ | WIZ | O95785 | 6/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23968577 | 0.93 | CRBN (0.54) | CRBNWIZIKZF2 | |
| SCHEMBL24788588 | 0.87 | CRBN (0.49) | CRBNWIZIKZF2MAPT | |
| SCHEMBL23968503 | 0.85 | LRRK2 (0.52) | CRBNMAPT | |
| SCHEMBL29648417 | 0.83 | CRBN (0.62) | CRBNWIZIKZF2MAPT | |
| SCHEMBL29648275 | 0.83 | CRBN (0.62) | CRBNWIZIKZF2MAPT | |
| SCHEMBL24501550 | 0.83 | CRBN (0.62) | CRBNWIZIKZF2MAPT | |
| SCHEMBL24696747 | 0.83 | CRBN (0.62) | CRBNWIZIKZF2MAPT | |
| SCHEMBL24696750 | 0.82 | CRBN (0.57) | CRBNWIZIKZF2MAPT | |
| SCHEMBL24938963 | 0.82 | CRBN (0.59) | CRBNWIZIKZF2 | |
| SCHEMBL22536038 | 0.82 | CRBN (0.57) | CRBNWIZIKZF2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | MDM2, CRBN, VHL | CRBN 2/4885WIZ 2539/4885IKZF2 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.