Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.54 |
| ▸ | WIZ | O95785 | 3/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23968543 | 0.93 | CRBN (0.51) | CRBNWIZIKZF2 | |
| SCHEMBL23968503 | 0.85 | LRRK2 (0.52) | CRBNIKZF3 | |
| SCHEMBL24788588 | 0.80 | CRBN (0.49) | CRBNWIZIKZF2 | |
| SCHEMBL20760056 | 0.80 | CRBN (0.72) | CRBNIKZF2 | |
| SCHEMBL29548034 | 0.79 | CRBN (0.61) | CRBNWIZ | |
| SCHEMBL27097903 | 0.79 | CRBN (0.61) | CRBNWIZ | |
| SCHEMBL27139685 | 0.79 | CRBN (0.67) | CRBNWIZ | |
| SCHEMBL19503629 | 0.76 | CRBN (0.72) | CRBNWIZIKZF2 | |
| SCHEMBL20234563 | 0.76 | CRBN (0.66) | CRBNWIZ | |
| SCHEMBL30007020 | 0.76 | CRBN (0.66) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | MDM2, CRBN, VHL | CRBN 2/4885WIZ 2539/4885IKZF2 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.