Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125309 | 0.82 | CHRM1 (0.50) | KMT2ACHRM1POLBKDM4ERAB9A | |
| SCHEMBL8189390 | 0.78 | KMT2A (0.43) | KMT2AMEN1HPGDPOLBRAB9A | |
| SCHEMBL3768429 | 0.74 | KMT2A (0.55) | KMT2AMEN1HPGDPOLBRAB9A | |
| SCHEMBL7862569 | 0.74 | KMT2A (0.47) | KMT2APOLBKDM4EEPHX2MMP1 | |
| SCHEMBL5407237 | 0.72 | MEN1 (0.52) | KMT2AMEN1HPGDPOLBRAB9A | |
| SCHEMBL7863949 | 0.72 | KMT2A (0.48) | KMT2APOLBKDM4EEPHX2ALDH1A1 | |
| SCHEMBL17685528 | 0.71 | MEN1 (0.38) | KMT2AMEN1HPGDPOLBRAB9A | |
| SCHEMBL7342669 | 0.71 | L3MBTL1 (0.49) | KMT2AMEN1EPHX2ALDH1A1L3MBTL1 | |
| SCHEMBL125438 | 0.70 | TSHR (0.42) | POLBKDM4ERAB9AEPHX2ALDH1A1 | |
| SCHEMBL7338141 | 0.70 | KMT2A (0.45) | KMT2ARAB9AEPHX2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904357-A1 | SPIRO COMPOUND AND MEDICAL USES THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd (CN) | 2021-11-03 | — | — | EP | disclosed |